Risk for ASD is strongly genetically influenced and reflects several types of genetic variation 1,2,3,4,5,6,7. Common polygenic variation, distributed across the genome, accounts for at least 20% of ...

In “What We Inherit,” Sam Trejo and Daphne O. Martschenko examine the link between genetic myths and social genomics.

Breakthroughs in genomics have begun to unravel the genetic architecture of schizophrenia risk, providing methods for quantifying schizophrenia polygenic risk based on common genetic variants. Our ...

Advances in genetics have made it possible to analyze thousands of genes at once, producing scores that estimate disease risk with high precision. But are polygenic risk scores ready to transform ...

Polygenic scores aim to measure the cumulative effect of multiple genetic variants to make predictions about a person’s health. The most likely areas of potential use are in risk prediction, including ...

Cost-utility studies provide critical information for the costs and benefits of using any new test, typically building on existing public health and screening programmes, within a defined population.